Emadine 5 Tab


Unit TAB
Manufacturer MERCK LIMITED
Indications Hypertension, angina pectoris and myocardial infarction
Contraindications Nursing mother & pregnancy.Known hypersensitivity to dihydropyridines.Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiop
Adverse Effects Headache, fatigue, ankle oedema, flushing, palpitation, tachycardia, nausea.Headache, peripheral oedema, fatigue, somnolence, nausea, abdominal pain, flushing, dyspepsia, palpitations, dizziness. Rarely pruritus, rash, dyspnoea, asthenia, muscle cramps FatalActions: Hypotension, bradycardia, conductive system delay and CCF
Drug Intercations Synergistic effects on angina with beta-blocker.Theophylline and phenytoin raise plasma level, reduce plasma level of quinidine Increased metabolism with rifampicin. Reduced hypotensive effect with calcium. Potentiates effects of thiazide diuretics and ACE inhibitors. Avoid combination with β-blockers in patients with markedly impaired left ventricular function. May increase serum levels of CYP1A2 substrates e.g. aminophylline, fluvoxamine, ropinirole. CYP3A4 inhibitors (e.g. clarithromycin, doxycycline, isoniazid, nicardipine) may increase the effects of amlodipine. Additive BP-lowering effects when used with sildenafil, tadalafil or vardenafil
Dosage As Prescribed by the Physician
Compatibility with Alcohol Not Enough Studies to Suggest the Risk
Intake During Pregnancy NA