Polybion Tablet


Composition Each film coated tablet contains Pyridoxine HCl 3 mg; Nicotinamide 100 mg; Cyanocobalamin Triturate in gelatin eq to Cyanocobalamin 15 mcg; Folic acid 1500 mcg; Chromium Picolinate 250 mcg; Seleniuos acid eq to Elemental Selenium 100 mcg; Zinc sulfate monohydrate 61.80 eq to 22.5 mg of elemental zinc
Therapeutic Indications Use in disease conditions involving high oxidative stress, such as diabetes mellitus, ischemic heart disease, COPD etc. Treatment of Vitamin B6, B12 and folic acid deficiency states particularly in patients recovering from chronic illness or debilitating state.
Dosage Adults- 1 tablet a day preferably to be taken with meal or as directed by the Physician.
Contraindications Previous intolerance or hypersensitivity to any ingredient of the formulation.
Warnings & Precautions It should not be used for newborn babies or premature infants. It should not be used for Leber’s disease or tobacco amblyopia, since these optic neuropathies may degenerate further. Avoid use in excess of the RDA during normal pregnancy or lactation. Avoid administration on empty stomach; zinc frequently causes gastrointestinal disturbances on oral administration especially on empty stomach. Polybion CZS tablet should only be given after confirming the diagnosis of deficiency states especially of folic acid and B12; regular monitoring of the blood is advisable. Full blood counts and serum cholesterol levels should be monitored to detect early signs of copper-deficiency on prolonged use.
Adverse Events Long-term use of large doses (2 to 6 g daily, for a period of 2 to 40 months) of pyridoxine (vitamin B6) is associated with the development of severe peripheral neuropathies. Cyanocobalamin may cause allergic skin reaction (generalized morbiliform exanthems, urticaria or generalized pruitus). Nicotinamide does not have nicotinic acid like adverse effects. It may cause gastrointestinal disturbances like nausea, vomiting, diarrhoea, abdominal pain or dyspepsia. Folic acid is generally well tolerated. Gastrointestinal disturbances and hypersensitivity reactions have been reported but rarely. Chromium-induced acute generalized exanthematous pustulosis and systemic contact dermatitis have been reported. Oral administration of zinc salts is frequently associated with gastrointestinal disturbances like abdominal pain, dyspepsia, nausea, vomiting, diarrhoea, gastrc irritation and gastritis. Prolonged use of high doses of zinc supplements leads to copper deficiency with associated sideroblastic anaemia and neutropenia.
Shelf-Life 18 Months
Storage Store at a temperature not exceeding 30°C protected from direct sunlight.
Keep out of the reach of Children